Are PIK3CA Mutation and Amplification Associated with Clinicopathological Characteristics of Gastric Cancer?

Authors
Hyunsu LeeIl-Seon HwangIn-Jang ChoiYu-Na KangKeon-Uk ParkJae-Ho Lee
Department
Dept. of Internal Medicine (내과학); Dept. of Anatomy (해부학); Dept. of Pathology (병리학)
Issue Date
2015
Citation
Asian Pacific Journal of Cancer Prevention, Vol.16(11) : 4493-4496, 2015
ISSN
1513-7368
Abstract
Alterations in mitochondrial DNA (mtDNA) have been studied in various cancers. However, the clinical value of mtDNA copy number (mtCN) alterations in gastric cancer (GC) is poorly understood. In the present study, we investigated whether alterations in mtCNs might be associated with clinicopathological parameters in GC cases. mtCN was measured in 109 patients with GC by real-time PCR. Then, correlations with clinicopathological characteristics were analyzed. mtCN was elevated in 64.2% of GC tissues compared with paired, adjacent, noncancerous tissue. However, the observed alterations in mtCN were not associated with any clinicopathological characteristics, including age, gender, TN stage, Lauren classification, lymph node metastasis, and depth of invasion. Moreover, Kaplan-Meier survival curves revealed that mtCN was not significantly associated with the survival of GC patients. In this study, we demonstrated that mtCN was not a significant marker for predicting clinical characteristics or prognosis in GC. Keywords: Gastric cancer - mitochondrial DNA - copy number - prognosis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35125
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
박건욱; 이현수; 최인장; 이재호; 황일선; 강유나
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