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Are PIK3CA Mutation and Amplification Associated with Clinicopathological Characteristics of Gastric Cancer?

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Author(s)
Hyunsu LeeIl-Seon HwangIn-Jang ChoiYu-Na KangKeon-Uk ParkJae-Ho Lee
Keimyung Author(s)
Park, Keon UkLee, Hyun SuChoi, In JangLee, Jae HoHwang, Il SeonKang, Yu Na
Department
Dept. of Internal Medicine (내과학)
Dept. of Anatomy (해부학)
Dept. of Pathology (병리학)
Journal Title
Asian Pacific Journal of Cancer Prevention
Issued Date
2015
Volume
16
Issue
11
Abstract
Alterations in mitochondrial DNA (mtDNA) have been studied in various cancers. However, the clinical value
of mtDNA copy number (mtCN) alterations in gastric cancer (GC) is poorly understood. In the present study,
we investigated whether alterations in mtCNs might be associated with clinicopathological parameters in GC
cases. mtCN was measured in 109 patients with GC by real-time PCR. Then, correlations with clinicopathological
characteristics were analyzed. mtCN was elevated in 64.2% of GC tissues compared with paired, adjacent, noncancerous
tissue. However, the observed alterations in mtCN were not associated with any clinicopathological
characteristics, including age, gender, TN stage, Lauren classification, lymph node metastasis, and depth of
invasion. Moreover, Kaplan-Meier survival curves revealed that mtCN was not significantly associated with the
survival of GC patients. In this study, we demonstrated that mtCN was not a significant marker for predicting
clinical characteristics or prognosis in GC.
Keywords: Gastric cancer - mitochondrial DNA - copy number - prognosis
Keimyung Author(s)(Kor)
박건욱
이현수
최인장
이재호
황일선
강유나
Publisher
School of Medicine
Citation
Hyunsu Lee et al. (2015). Are PIK3CA Mutation and Amplification Associated with Clinicopathological Characteristics of Gastric Cancer? Asian Pacific Journal of Cancer Prevention, 16(11), 4493–4496. doi: 10.7314/APJCP.2015.16.11.4493
Type
Article
ISSN
1513-7368
DOI
10.7314/APJCP.2015.16.11.4493
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35125
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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