Are PIK3CA Mutation and Amplification Associated with Clinicopathological Characteristics of Gastric Cancer?
- Affiliated Author(s)
- 박건욱; 이현수; 최인장; 이재호; 황일선; 강유나
- Alternative Author(s)
- Park, Keon Uk; Lee, Hyun Su; Choi, In Jang; Lee, Jae Ho; Hwang, Il Seon; Kang, Yu Na
- Journal Title
- Asian Pacific Journal of Cancer Prevention
- Issued Date
- Alterations in mitochondrial DNA (mtDNA) have been studied in various cancers. However, the clinical value
of mtDNA copy number (mtCN) alterations in gastric cancer (GC) is poorly understood. In the present study,
we investigated whether alterations in mtCNs might be associated with clinicopathological parameters in GC
cases. mtCN was measured in 109 patients with GC by real-time PCR. Then, correlations with clinicopathological
characteristics were analyzed. mtCN was elevated in 64.2% of GC tissues compared with paired, adjacent, noncancerous
tissue. However, the observed alterations in mtCN were not associated with any clinicopathological
characteristics, including age, gender, TN stage, Lauren classification, lymph node metastasis, and depth of
invasion. Moreover, Kaplan-Meier survival curves revealed that mtCN was not significantly associated with the
survival of GC patients. In this study, we demonstrated that mtCN was not a significant marker for predicting
clinical characteristics or prognosis in GC.
Keywords: Gastric cancer - mitochondrial DNA - copy number - prognosis
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