Microsatellite Instability of Nuclear and Mitochondrial DNAs in Gastric Carcinogenesis

Authors
Jae-Ho LeeDae-Kwang Kim
Department
Dept. of Anatomy (해부학); Dept. of Medical Genetics(의학유전학); Institute for Cancer Research (암연구소)
Issue Date
2014
Citation
Asian Pacific Journal of Cancer Prevention, Vol.15(19) : 8027-8034, 2014
ISSN
1513-7368
Abstract
Genetic instability contributes to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Microsatellite instability (MSI) has been hypothesized to be involved in carcinogenesis, althgough its mechanisms and exact roles in gastric cancer remain largely unknown. Our aim was to identify associated clinicopathological characteristics and prognostic value of MSI in gastric cancer and precancerous lesions including gastritis, metaplasia, dysplasia, and adenoma. Because mitochondrial DNA has a different genetic system from nuclear DNA, the results of both nuclear MSI and mitochondrial MSI in gastric cancer were reviewed. This review provides evidence that genetic instability of nuclear and mitochondrial DNAs contributes to early stages of gastric carcinogenesis and suggests possible roles in predicting prognosis. Keywords: Gastric cancer - dysplasia - metaplasia - microsatellite instability - mitochondrial microsatellite instability
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35128
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
Keimyung Author(s)
이재호; 김대광
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