계명대학교 의학도서관 Repository

Microsatellite Instability of Nuclear and Mitochondrial DNAs in Gastric Carcinogenesis

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Author(s)
Jae-Ho LeeDae-Kwang Kim
Keimyung Author(s)
Lee, Jae HoKim, Dae Kwang
Department
Dept. of Anatomy (해부학)
Dept. of Medical Genetics(의학유전학)
Institute for Cancer Research (암연구소)
Journal Title
Asian Pacific Journal of Cancer Prevention
Issued Date
2014
Volume
15
Issue
19
Abstract
Genetic instability contributes to the development and progression of gastric cancer, one of the leading
causes of cancer death worldwide. Microsatellite instability (MSI) has been hypothesized to be involved in
carcinogenesis, althgough its mechanisms and exact roles in gastric cancer remain largely unknown. Our aim
was to identify associated clinicopathological characteristics and prognostic value of MSI in gastric cancer and
precancerous lesions including gastritis, metaplasia, dysplasia, and adenoma. Because mitochondrial DNA has
a different genetic system from nuclear DNA, the results of both nuclear MSI and mitochondrial MSI in gastric
cancer were reviewed. This review provides evidence that genetic instability of nuclear and mitochondrial DNAs
contributes to early stages of gastric carcinogenesis and suggests possible roles in predicting prognosis.
Keywords: Gastric cancer - dysplasia - metaplasia - microsatellite instability - mitochondrial microsatellite instability
Keimyung Author(s)(Kor)
이재호
김대광
Publisher
School of Medicine
Citation
Jae-Ho Lee and Dae-Kwang Kim. (2014). Microsatellite Instability of Nuclear and Mitochondrial DNAs in Gastric Carcinogenesis. Asian Pacific Journal of Cancer Prevention, 15(19), 8027–8034. doi: 10.7314/APJCP.2014.15.19.8027
Type
Article
ISSN
1513-7368
DOI
10.7314/APJCP.2014.15.19.8027
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35128
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
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