The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma
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- Cho, Chi Heum
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- Aims: We performed an age-matched case–control study to compare the clinical and pathology outcomes between
histologically diagnosed primary malignant mixed m}ullerian tumour (MMMT) of the uterus and endometrial carcinoma.
Methods: Thirty-two women were treated for primary MMMT at seven tertiary medical centres in Korea from 2000 to
2006. For each woman with MMMT, four women with endometrioid and two with non-endometrioid endometrial
carcinoma were selected as age-matched controls for analysis. Medical records were retrospectively reviewed to obtain
Results: The incidence of MMMT was 2.57% (32 ⁄ 1244). In comparison with women with endometrioid endometrial
cancer, those with MMMT were characterised by large tumour size, higher incidence of adnexal involvement and lymph
node metastases, leading to advanced disease stage. Despite the frequent use of adjuvant treatment, the 5-year survival
rate of women with MMMT was significantly poorer than those with endometrioid endometrial cancer. However, women
with MMMT were not significantly different from those with non-endometrioid endometrial cancer in terms of important
pathologic variables, apart from larger tumour size. In addition, the 5-year survival rate of women MMMT was poorer
than that those with non-endometrioid endometrial cancer, but the difference was not statistically significant.
Conclusions: Malignant mixed m}ullerian tumour is characterised by a high incidence of lymph node metastases and
advanced stage at diagnosis, leading to poorer overall survival than other subtypes of endometrial carcinoma. Clinical
trials for MMMTare critical for improving treatment strategies.
Key words: endometrial cancer, malignant mixed m}ullerian tumour, prognosis, survival.
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