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The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma

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Author(s)
Seo-Yun TONGJong-Min LEEYoung-Joon CHOIJae-Kwan LEEJao Weon KIMChi-Heum CHOSeok-Mo KIMSang-Yoon PARKChan-Yong PARKKi-Tae KIM
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Australian and New Zealand Journal of Obstetrics and Gynaecology
Issued Date
2012
Volume
52
Issue
1
Abstract
Aims: We performed an age-matched case–control study to compare the clinical and pathology outcomes between
histologically diagnosed primary malignant mixed m}ullerian tumour (MMMT) of the uterus and endometrial carcinoma.
Methods: Thirty-two women were treated for primary MMMT at seven tertiary medical centres in Korea from 2000 to
2006. For each woman with MMMT, four women with endometrioid and two with non-endometrioid endometrial
carcinoma were selected as age-matched controls for analysis. Medical records were retrospectively reviewed to obtain
outcome data.
Results: The incidence of MMMT was 2.57% (32 ⁄ 1244). In comparison with women with endometrioid endometrial
cancer, those with MMMT were characterised by large tumour size, higher incidence of adnexal involvement and lymph
node metastases, leading to advanced disease stage. Despite the frequent use of adjuvant treatment, the 5-year survival
rate of women with MMMT was significantly poorer than those with endometrioid endometrial cancer. However, women
with MMMT were not significantly different from those with non-endometrioid endometrial cancer in terms of important
pathologic variables, apart from larger tumour size. In addition, the 5-year survival rate of women MMMT was poorer
than that those with non-endometrioid endometrial cancer, but the difference was not statistically significant.
Conclusions: Malignant mixed m}ullerian tumour is characterised by a high incidence of lymph node metastases and
advanced stage at diagnosis, leading to poorer overall survival than other subtypes of endometrial carcinoma. Clinical
trials for MMMTare critical for improving treatment strategies.
Key words: endometrial cancer, malignant mixed m}ullerian tumour, prognosis, survival.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
Seo-Yun TONG et al. (2012). The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma. Australian and New Zealand Journal of Obstetrics and Gynaecology, 52(1), 44–48. doi: 10.1111/j.1479-828X.2011.01389.x
Type
Article
ISSN
1479-828X
Source
https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/j.1479-828X.2011.01389.x
DOI
10.1111/j.1479-828X.2011.01389.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35142
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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