D-Glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K

Authors
Hyun-Ji OhJason S. LeeDae-Kyu SongDong-Hoon ShinByeong-Churl JangSeong-Il SuhJong-Wook ParkMin-Ho SuhWon-Ki Baek
Department
Dept. of Physiology (생리학); Dept. of Preventive Medicine (예방의학); Dept. of Molecular Medicine (분자의학); Dept. of Microbiology (미생물학); Dept. of Immunology (면역학); Institute for Medical Science (의과학연구소)
Issue Date
2007
Citation
Biochemical and Biophysical Research Communications, Vol.360(4) : 840-845, 2007
ISSN
0006-291X
Abstract
Although d-glucosamine has been reported as an inhibitor of tumor growth both in vivo and in vitro, the mechanism for the anticancer effect of d-glucosamine is still unclear. Since there are several reports suggesting d-glucosamine inhibits protein synthesis, we examined whether d-glucosamine affects p70S6 K activity, an important signaling molecule involved in protein translation. In the present study, we found d-glucosamine inhibited the activity of p70S6K and the proliferation of DU145 prostate cancer cells and MDA-MB-231 breast cancer cells. d-Glucosamine decreased phosphorylation of p70S6K, and its downstream substrates RPS6, and eIF-4B, but not mTOR and 4EBP1 in DU145 cells, suggesting that d-glucosamine induced inhibition of p70S6K is not through the inhibition of mTOR. In addition, d-glucosamine enhanced the growth inhibitory effects of rapamycin, a specific inhibitor of mTOR. These findings suggest that d-glucosamine can inhibit growth of cancer cells through dephosphorylation of p70S6K. Keywords d-Glucosamine; p70S6K; RPS6; Cell proliferation; Prostate cancer; Breast cancer
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35144
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
Keimyung Author(s)
송대규; 신동훈; 장병철; 서성일; 박종욱; 서민호; 백원기
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0006291X07014064
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