Axl is a novel target of withaferin A in the induction of apoptosis and the suppression of invasion

Authors
Seon Min WooKyoung-jin MinShin KimJong-Wook ParkDong Eun KimSang Hyun KimYung Hyun ChoiTaeg Kyu Kwon
Department
Dept. of Immunology (면역학); Dept. of Otorhinolaryngology (이비인후과학)
Issue Date
2014
Citation
Biochemical and Biophysical Research Communications, Vol.451(3) : 455-460, 2014
ISSN
0006-291X
Abstract
Withaferin A, a withanolide derived from the medicinal plant Withania somnifera, has been reported to exhibit anti-tumorigenic activity against various cancer cells. In this study, we show that withaferin A inhibits the constitutive and recombinant human growth-arrest-specific protein 6 (rhGas6)-induced phosphorylation of Axl and STAT3. In addition, withaferin A also induces the down-regulation of Axl protein expression in a lysosome-dependent manner and inhibits rhGas6-induced wound healing and cell migration. Furthermore, the overexpression of Axl attenuates withaferin A-induced apoptosis. Taken together, the data from the present study indicate that the withaferin A-mediated down-regulation of the Gas6/Axl signaling pathway mediates the inhibition of cell migration and the induction of apoptosis. Keywords Withaferin A; Axl; Gas6; Migration; Apoptosis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35155
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
Keimyung Author(s)
김신; 박종욱; 권택규; 김동은
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0006291X14014247
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE