Axl is a novel target of withaferin A in the induction of apoptosis
and the suppression of invasion
- Author(s)
- Seon Min Woo; Kyoung-jin Min; Shin Kim; Jong-Wook Park; Dong Eun Kim; Sang Hyun Kim; Yung Hyun Choi; Taeg Kyu Kwon
- Publication Year
- 2014
- Abstract
- Withaferin A, a withanolide derived from the medicinal plant Withania somnifera, has been reported to exhibit anti-tumorigenic activity against various cancer cells. In this study, we show that withaferin A inhibits the constitutive and recombinant human growth-arrest-specific protein 6 (rhGas6)-induced phosphorylation of Axl and STAT3. In addition, withaferin A also induces the down-regulation of Axl protein expression in a lysosome-dependent manner and inhibits rhGas6-induced wound healing and cell migration. Furthermore, the overexpression of Axl attenuates withaferin A-induced apoptosis. Taken together, the data from the present study indicate that the withaferin A-mediated down-regulation of the Gas6/Axl signaling pathway mediates the inhibition of cell migration and the induction of apoptosis.
Keywords
Withaferin A;
Axl;
Gas6;
Migration;
Apoptosis
- Authorize & License
-
- AuthorizeOpen
- EmbargoForever
- Files in This Item:
-
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.