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Axl is a novel target of withaferin A in the induction of apoptosis and the suppression of invasion

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Author(s)
Seon Min WooKyoung-jin MinShin KimJong-Wook ParkDong Eun KimSang Hyun KimYung Hyun ChoiTaeg Kyu Kwon
Publication Year
2014
Abstract
Withaferin A, a withanolide derived from the medicinal plant Withania somnifera, has been reported to exhibit anti-tumorigenic activity against various cancer cells. In this study, we show that withaferin A inhibits the constitutive and recombinant human growth-arrest-specific protein 6 (rhGas6)-induced phosphorylation of Axl and STAT3. In addition, withaferin A also induces the down-regulation of Axl protein expression in a lysosome-dependent manner and inhibits rhGas6-induced wound healing and cell migration. Furthermore, the overexpression of Axl attenuates withaferin A-induced apoptosis. Taken together, the data from the present study indicate that the withaferin A-mediated down-regulation of the Gas6/Axl signaling pathway mediates the inhibition of cell migration and the induction of apoptosis.

Keywords
Withaferin A;
Axl;
Gas6;
Migration;
Apoptosis
Department
Dept. of Immunology (면역학)
Dept. of Otorhinolaryngology (이비인후과학)
Publisher
School of Medicine
Citation
Biochemical and Biophysical Research Communications, Vol.451(3) : 455-460, 2014
Type
Article
ISSN
0006-291X
DOI
10.1016/j.bbrc.2014.08.018
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35155
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