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Axl is a novel target of withaferin A in the induction of apoptosis and the suppression of invasion

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Author(s)
Seon Min WooKyoung-jin MinShin KimJong-Wook ParkDong Eun KimSang Hyun KimYung Hyun ChoiTaeg Kyu Kwon
Keimyung Author(s)
Kim, ShinPark, Jong WookKwon, Taeg KyuKim, Dong Eun
Department
Dept. of Immunology (면역학)
Dept. of Otorhinolaryngology (이비인후과학)
Journal Title
Biochemical and Biophysical Research Communications
Issued Date
2014
Volume
451
Issue
3
Abstract
Withaferin A, a withanolide derived from the medicinal plant Withania somnifera, has been reported to exhibit anti-tumorigenic activity against various cancer cells. In this study, we show that withaferin A inhibits the constitutive and recombinant human growth-arrest-specific protein 6 (rhGas6)-induced phosphorylation of Axl and STAT3. In addition, withaferin A also induces the down-regulation of Axl protein expression in a lysosome-dependent manner and inhibits rhGas6-induced wound healing and cell migration. Furthermore, the overexpression of Axl attenuates withaferin A-induced apoptosis. Taken together, the data from the present study indicate that the withaferin A-mediated down-regulation of the Gas6/Axl signaling pathway mediates the inhibition of cell migration and the induction of apoptosis.

Keywords
Withaferin A;
Axl;
Gas6;
Migration;
Apoptosis
Keimyung Author(s)(Kor)
김신
박종욱
권택규
김동은
Publisher
School of Medicine
Citation
Seon Min Woo et al. (2014). Axl is a novel target of withaferin A in the induction of apoptosis
and the suppression of invasion. Biochemical and Biophysical Research Communications, 451(3), 455–460. doi: 10.1016/j.bbrc.2014.08.018
Type
Article
ISSN
0006-291X
Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X14014247
DOI
10.1016/j.bbrc.2014.08.018
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35155
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
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