Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors

Authors
Jinho LeeHwangeun ChoiKyoung-Hee KimShinwu JeongJong-Wook ParkChul-Su BaekSei-Hee Lee
Department
Dept. of Immunology (면역학)
Issue Date
2008
Citation
Bioorganic & Medicinal Chemistry Letters, Vol.18(7) : 2292-2295, 2008
ISSN
0960-894X
Abstract
A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35219
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
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Full Text
https://www.sciencedirect.com/science/article/pii/S0960894X08002606?via%3Dihub
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