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Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors

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Author(s)
박종욱
Alternative Author(s)
Park, Jong Wook
Publication Year
2008
Abstract
A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Bioorganic & Medicinal Chemistry Letters, Vol.18(7) : 2292-2295, 2008
Type
Article
ISSN
0960-894X
DOI
10.1016/j.bmcl.2008.03.002
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35219
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