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Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors

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Author(s)
Jinho LeeHwangeun ChoiKyoung-Hee KimShinwu JeongJong-Wook ParkChul-Su BaekSei-Hee Lee
Keimyung Author(s)
Park, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
Bioorganic & Medicinal Chemistry Letters
Issued Date
2008
Volume
18
Issue
7
Abstract
A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
Keimyung Author(s)(Kor)
박종욱
Publisher
School of Medicine
Citation
Jinho Lee et al. (2008). Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorganic & Medicinal Chemistry Letters, 18(7), 2292–2295. doi: 10.1016/j.bmcl.2008.03.002
Type
Article
ISSN
0960-894X
Source
https://www.sciencedirect.com/science/article/pii/S0960894X08002606?via%3Dihub
DOI
10.1016/j.bmcl.2008.03.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35219
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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