Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors
- Keimyung Author(s)
- Park, Jong Wook
- Department
- Dept. of Immunology (면역학)
- Journal Title
- Bioorganic & Medicinal Chemistry Letters
- Issued Date
- 2008
- Volume
- 18
- Issue
- 7
- Abstract
- A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
- Keimyung Author(s)(Kor)
- 박종욱
- Publisher
- School of Medicine
- Citation
- Jinho Lee et al. (2008). Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorganic & Medicinal Chemistry Letters, 18(7), 2292–2295. doi: 10.1016/j.bmcl.2008.03.002
- Type
- Article
- ISSN
- 0960-894X
- Source
- https://www.sciencedirect.com/science/article/pii/S0960894X08002606?via%3Dihub
- Appears in Collections:
- 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
- 파일 목록
-
-
Download
oak-aaa-00638.pdf
기타 데이터 / 628.81 kB / Adobe PDF
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.