Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC

Authors
Seunguk PaikMyung Kwang ParkSeong Hoon JhunHeai Ku ParkChun Soo LeeBum Rae ChoHong Sik ByunSeok Burm ChoeSeong Il Suh
Department
Dept. of Microbiology (미생물학); Dept. of Radiology (영상의학)
Issue Date
2003
Citation
Bulletin of the Korean Chemical Society, Vol.24(5) : 623-626, 2003
ISSN
0253-2964
Abstract
Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin. Key Words : Xenorhabdus nematophilus, Staphylococcus aureus, Nematophin, Tryptamine, L-Isoleucine
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35272
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
Keimyung Author(s)
서성일; 백승국
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