Dept. of Microbiology (미생물학); Dept. of Radiology (영상의학)
Bulletin of the Korean Chemical Society, Vol.24(5) : 623-626, 2003
Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin.
Key Words : Xenorhabdus nematophilus, Staphylococcus aureus, Nematophin, Tryptamine, L-Isoleucine