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Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC

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Author(s)
Seunguk PaikMyung Kwang ParkSeong Hoon JhunHeai Ku ParkChun Soo LeeBum Rae ChoHong Sik ByunSeok Burm ChoeSeong Il Suh
Keimyung Author(s)
Suh, Seong IlBaik, Seung Kug
Department
Dept. of Microbiology (미생물학)
Dept. of Radiology (영상의학)
Journal Title
Bulletin of the Korean Chemical Society
Issued Date
2003
Volume
24
Issue
5
Abstract
Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin.
Key Words : Xenorhabdus nematophilus, Staphylococcus aureus, Nematophin, Tryptamine, L-Isoleucine
Keimyung Author(s)(Kor)
서성일
백승국
Publisher
School of Medicine
Citation
Seunguk Paik et al. (2003). Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC. Bulletin of the Korean Chemical Society, 24(5), 623–626. doi: 10.5012/bkcs.2003.24.5.623
Type
Article
ISSN
0253-2964
DOI
10.5012/bkcs.2003.24.5.623
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35272
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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