A specific chromosome aberration in a keratoacanthoma
- Dae-Kwang Kim; Joo-Young Kim; Hyeung-Tae Kim; Ki-Hwan Han; Dae-Gu Shon
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- Specific cytogenetic changes observed in various tumors indicate that a chromosomal event may play a key role in malignant transformation. We present a patient with keratoacanthoma with a sole chromosome abnormality. The karyotype found in short-term culture was 46,XY,t(2;8)(p13;p23); a normal male chromosome complement was also found. The finding of t(2;8) as a sole anomaly suggests that this aberration is a primary change in keratoacanthoma and might be important in the pathobiology of this tumor.
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