Dept. of Pathology (병리학); Dept. of Biochemistry (생화학); Dept. of Pharmacology (약리학); Dept. of Immunology (면역학); Dept. of Microbiology (미생물학); Dept. of Surgery (외과학)Institute for Medical Science (의과학연구소)
Cancer Letters, Vol.195(1) : 87-91, 2003
The bcl-2 homologue antagonist/killer (BAK) is a potently apoptosis-inducing gene and plays an important role in modulating apoptosis in epithelial cells. We have analyzed the mutation of the entire coding region of BAK gene in 107 Korean advanced gastric adenocarcinomas by polymerase chain reaction-single strand conformation polymorphism and sequencing. Homozygous deletions were not found in these samples. Only three cases of 107 gastric adenocarcinomas (2.8%) exhibited the BAK mutations. Two of them exhibited missense mutations and the remaining one had a silent mutation. All of these mutations were exclusively detected in exon 2. Mutations in the BAK gene were observed only in advanced gastric adenocarcinomas with extensive metastases of regional lymph nodes. The data presented here suggest that the mutations of BAK gene rarely occurred in advanced gastric adenocarcinomas.
Author Keywords : BAK gene; Mutation; Advanced gastric adenocarcinoma