Mutations of the BAK gene are infrequent in advanced gastric adenocarcinomas in Koreans

Authors
Sang-Pyo KimMi-Sun HwangYoung Rok ChoSun Young KwonYu-Na KangIn-Ho KimSoo-Sang SohnKyo-Cheol MunTaeg Kyu KwonSeong-Ryong LeeSeong-Il Suh
Department
Dept. of Pathology (병리학); Dept. of Biochemistry (생화학); Dept. of Pharmacology (약리학); Dept. of Immunology (면역학); Dept. of Microbiology (미생물학); Dept. of Surgery (외과학)Institute for Medical Science (의과학연구소)
Issue Date
2003
Citation
Cancer Letters, Vol.195(1) : 87-91, 2003
ISSN
0304-3835
Abstract
The bcl-2 homologue antagonist/killer (BAK) is a potently apoptosis-inducing gene and plays an important role in modulating apoptosis in epithelial cells. We have analyzed the mutation of the entire coding region of BAK gene in 107 Korean advanced gastric adenocarcinomas by polymerase chain reaction-single strand conformation polymorphism and sequencing. Homozygous deletions were not found in these samples. Only three cases of 107 gastric adenocarcinomas (2.8%) exhibited the BAK mutations. Two of them exhibited missense mutations and the remaining one had a silent mutation. All of these mutations were exclusively detected in exon 2. Mutations in the BAK gene were observed only in advanced gastric adenocarcinomas with extensive metastases of regional lymph nodes. The data presented here suggest that the mutations of BAK gene rarely occurred in advanced gastric adenocarcinomas. Author Keywords : BAK gene; Mutation; Advanced gastric adenocarcinoma
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35313
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
Keimyung Author(s)
김상표; 문교철; 권택규; 이성용; 서성일; 김인호; 손수상; 권선영; 강유나
Full Text
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304383502005852?via%3Dihub
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