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Mutations of the BAK gene are infrequent in advanced gastric adenocarcinomas in Koreans

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Affiliated Author(s)
김상표문교철권택규이성용서성일김인호손수상권선영강유나
Alternative Author(s)
Kim, Sang PyoMun, Kyo CheolKwon, Taeg KyuLee, Seong RyongSuh, Seong IlKim, In HoSohn, Soo SangKwon, Sun YoungKang, Yu Na
Journal Title
Cancer Letters
ISSN
0304-3835
Issued Date
2003
Abstract
The bcl-2 homologue antagonist/killer (BAK) is a potently apoptosis-inducing gene and plays an important role in modulating apoptosis in epithelial cells. We have analyzed the mutation of the entire coding region of BAK gene in 107 Korean advanced gastric adenocarcinomas by polymerase chain reaction-single strand conformation polymorphism and sequencing. Homozygous deletions were not found in these samples. Only three cases of 107 gastric adenocarcinomas (2.8%) exhibited the BAK mutations. Two of them exhibited missense mutations and the remaining one had a silent mutation. All of these mutations were exclusively detected in exon 2. Mutations in the BAK gene were observed only in advanced gastric adenocarcinomas with extensive metastases of regional lymph nodes. The data presented here suggest that the mutations of BAK gene rarely occurred in advanced gastric adenocarcinomas.

Author Keywords : BAK gene; Mutation; Advanced gastric adenocarcinoma
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