Mutations of the BAK gene are infrequent in advanced gastric adenocarcinomas in Koreans
- Affiliated Author(s)
- 김상표; 문교철; 권택규; 이성용; 서성일; 김인호; 손수상; 권선영; 강유나
- Alternative Author(s)
- Kim, Sang Pyo; Mun, Kyo Cheol; Kwon, Taeg Kyu; Lee, Seong Ryong; Suh, Seong Il; Kim, In Ho; Sohn, Soo Sang; Kwon, Sun Young; Kang, Yu Na
- Journal Title
- Cancer Letters
- Issued Date
- The bcl-2 homologue antagonist/killer (BAK) is a potently apoptosis-inducing gene and plays an important role in modulating apoptosis in epithelial cells. We have analyzed the mutation of the entire coding region of BAK gene in 107 Korean advanced gastric adenocarcinomas by polymerase chain reaction-single strand conformation polymorphism and sequencing. Homozygous deletions were not found in these samples. Only three cases of 107 gastric adenocarcinomas (2.8%) exhibited the BAK mutations. Two of them exhibited missense mutations and the remaining one had a silent mutation. All of these mutations were exclusively detected in exon 2. Mutations in the BAK gene were observed only in advanced gastric adenocarcinomas with extensive metastases of regional lymph nodes. The data presented here suggest that the mutations of BAK gene rarely occurred in advanced gastric adenocarcinomas.
Author Keywords : BAK gene; Mutation; Advanced gastric adenocarcinoma
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