Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells
- Jong-Wook Park; Yun-Jung Choi; Min-Ah Jang; Young-Sun Lee; Do Youn Jun; Seong-Il Suh; Won-Ki Baek; Min-Ho Suh; Ing-Nyol Jin; Taeg Kyu Kwon
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- Resveratrol, a natural product derived from grapes, has been shown to prevent carcinogenesis in murine models. We report here that resveratrol induces antiproliferation and arrests the S phase in human histiocytic lymphoma U937 cells. Resveratrol induces arrest in the S phase at low concentrations (30–60 μM), but high concentrations do not induce S phase accumulation in U937 cells. Removal of resveratrol from the culture medium stimulates U937 cells to reenter the cell cycle synchronously, as judged by the expression patterns of cyclin E, A and by fluorescent activated cell sorting analysis. These data demonstrate that resveratrol causes S phase arrest and reversible cell cycle arrest. Thus, resveratrol provides an important new cell cycle blocker as well as a cancer chemopreventive agent.
Keywords : Resveratrol; Cell cycle; Cyclin; Cancer chemopreventive agent
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