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Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells

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Author(s)
Jong-Wook ParkYun-Jung ChoiMin-Ah JangYoung-Sun LeeDo Youn JunSeong-Il SuhWon-Ki BaekMin-Ho SuhIng-Nyol JinTaeg Kyu Kwon
Publication Year
2001
Abstract
Resveratrol, a natural product derived from grapes, has been shown to prevent carcinogenesis in murine models. We report here that resveratrol induces antiproliferation and arrests the S phase in human histiocytic lymphoma U937 cells. Resveratrol induces arrest in the S phase at low concentrations (30–60 μM), but high concentrations do not induce S phase accumulation in U937 cells. Removal of resveratrol from the culture medium stimulates U937 cells to reenter the cell cycle synchronously, as judged by the expression patterns of cyclin E, A and by fluorescent activated cell sorting analysis. These data demonstrate that resveratrol causes S phase arrest and reversible cell cycle arrest. Thus, resveratrol provides an important new cell cycle blocker as well as a cancer chemopreventive agent.

Keywords : Resveratrol; Cell cycle; Cyclin; Cancer chemopreventive agent
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Cancer Letters, Vol.163(1) : 43-49, 2001
Type
Article
ISSN
0304-3835
DOI
10.1016/S0304-3835(00)00658-3
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35318
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