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Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells

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Author(s)
Jong-Wook ParkYun-Jung ChoiMin-Ah JangYoung-Sun LeeDo Youn JunSeong-Il SuhWon-Ki BaekMin-Ho SuhIng-Nyol JinTaeg Kyu Kwon
Keimyung Author(s)
Suh, Min HoSuh, Seong IlBaek, Won KiPark, Jong WookKwon, Taeg Kyu
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Journal Title
Cancer Letters
Issued Date
2001
Volume
163
Issue
1
Abstract
Resveratrol, a natural product derived from grapes, has been shown to prevent carcinogenesis in murine models. We report here that resveratrol induces antiproliferation and arrests the S phase in human histiocytic lymphoma U937 cells. Resveratrol induces arrest in the S phase at low concentrations (30–60 μM), but high concentrations do not induce S phase accumulation in U937 cells. Removal of resveratrol from the culture medium stimulates U937 cells to reenter the cell cycle synchronously, as judged by the expression patterns of cyclin E, A and by fluorescent activated cell sorting analysis. These data demonstrate that resveratrol causes S phase arrest and reversible cell cycle arrest. Thus, resveratrol provides an important new cell cycle blocker as well as a cancer chemopreventive agent.

Keywords : Resveratrol; Cell cycle; Cyclin; Cancer chemopreventive agent
Keimyung Author(s)(Kor)
서민호
서성일
백원기
박종욱
권택규
Publisher
School of Medicine
Citation
Jong-Wook Park et al. (2001). Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells. Cancer Letters, 163(1), 43–49. doi: 10.1016/S0304-3835(00)00658-3
Type
Article
ISSN
0304-3835
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304383500006583?via%3Dihub
DOI
10.1016/S0304-3835(00)00658-3
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35318
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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