Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

Authors
Min Ji AnJae Hee CheonSeung Won KimEun Soo KimTae Il KimWon Ho Kim
Department
Dept. of Internal Medicine (내과학)
Issue Date
2009
Citation
Cancer Letters, Vol.279(1) : 93-100, 2009
ISSN
0304-3835
Abstract
The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer. Keywords : Guggulsterone; Colorectal cancer; Apoptosis; Xenograft
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35320
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
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Full Text
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304383509000603?via%3Dihub
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