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Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

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Author(s)
김은수
Alternative Author(s)
Kim, Eun Soo
Publication Year
2009
Abstract
The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer.

Keywords : Guggulsterone; Colorectal cancer; Apoptosis; Xenograft
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Cancer Letters, Vol.279(1) : 93-100, 2009
Type
Article
ISSN
0304-3835
DOI
10.1016/j.canlet.2009.01.026
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35320
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