계명대학교 의학도서관 Repository

Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

Metadata Downloads
Author(s)
Min Ji AnJae Hee CheonSeung Won KimEun Soo KimTae Il KimWon Ho Kim
Keimyung Author(s)
Kim, Eun Soo
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Letters
Issued Date
2009
Volume
279
Issue
1
Abstract
The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer.

Keywords : Guggulsterone; Colorectal cancer; Apoptosis; Xenograft
Keimyung Author(s)(Kor)
김은수
Publisher
School of Medicine
Citation
Min Ji An et al. (2009). Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. Cancer Letters, 279(1), 93–100. doi: 10.1016/j.canlet.2009.01.026
Type
Article
ISSN
0304-3835
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304383509000603?via%3Dihub
DOI
10.1016/j.canlet.2009.01.026
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35320
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.