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Expression of RB C pocket fragments in HSF induces delayed cell cycle progression and sensitizes to apoptosis upon cellular stresses

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Author(s)
Junah ChungJae-We ChoWon-Ki BaekSeong-Il SuhTaeg Kyu KwonJong-Wook ParkMin-Ho Suh
Publication Year
2002
Abstract
The retinoblastoma protein (RB) plays an important role in growth suppression through the formation of multiple protein complexes with its target proteins using A/B and C pockets. Even though the A/B and C pockets co-operate for growth suppression, the function of RB in growth arrest is inhibited by the coexpression of RB C fragments with full length RB in the absence of p53, which implies that C pocket fragments are likely to act as a dominant-negative inhibitor of RB function. In contrast, the loss of the RB functions in the presence of p53 triggers a cell cycle arrest or apoptosis by p53-dependent pathways. Thus, it still remains to be elucidated whether the expression of RB C pocket fragments in the presence of p53 induces delayed cell cycle progression and sensitizes cells to apoptosis through p53-dependent pathways. Our results show that the expression of RB C pocket fragments not only induces delayed cell cycle progression, which is mediated by the down-regulation of cyclin A, cyclin E, and E2F-1, but also sensitizes cells to apoptosis through p53-dependent pathways.
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Cell Proliferation, Vol.35(4) : 247-256, 2002
Type
Article
ISSN
0960-7722
DOI
10.1046/j.1365-2184.2002.00245.x
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35382
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