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Expression of RB C pocket fragments in HSF induces delayed cell cycle progression and sensitizes to apoptosis upon cellular stresses

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Author(s)
Junah ChungJae-We ChoWon-Ki BaekSeong-Il SuhTaeg Kyu KwonJong-Wook ParkMin-Ho Suh
Keimyung Author(s)
Baek, Won KiSuh, Seong IlSuh, Min HoKwon, Taeg KyuPark, Jong Wook
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Journal Title
Cell Proliferation
Issued Date
2002
Volume
35
Issue
4
Abstract
The retinoblastoma protein (RB) plays an important role in growth suppression through the formation of multiple protein complexes with its target proteins using A/B and C pockets. Even though the A/B and C pockets co-operate for growth suppression, the function of RB in growth arrest is inhibited by the coexpression of RB C fragments with full length RB in the absence of p53, which implies that C pocket fragments are likely to act as a dominant-negative inhibitor of RB function. In contrast, the loss of the RB functions in the presence of p53 triggers a cell cycle arrest or apoptosis by p53-dependent pathways. Thus, it still remains to be elucidated whether the expression of RB C pocket fragments in the presence of p53 induces delayed cell cycle progression and sensitizes cells to apoptosis through p53-dependent pathways. Our results show that the expression of RB C pocket fragments not only induces delayed cell cycle progression, which is mediated by the down-regulation of cyclin A, cyclin E, and E2F-1, but also sensitizes cells to apoptosis through p53-dependent pathways.
Keimyung Author(s)(Kor)
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서민호
권택규
박종욱
Publisher
School of Medicine
Citation
Junah Chung et al. (2002). Expression of RB C pocket fragments in HSF induces delayed cell cycle progression and sensitizes to apoptosis upon cellular stresses. Cell Proliferation, 35(4), 247–256. doi: 10.1046/j.1365-2184.2002.00245.x
Type
Article
ISSN
0960-7722
Source
https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2184.2002.00245.x
DOI
10.1046/j.1365-2184.2002.00245.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35382
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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