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Microglial Phagocytosis of Dopamine Neurons at Early Phases of Apoptosis

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Author(s)
신동훈
Alternative Author(s)
Shin, Dong Hoon
Publication Year
2003
Abstract
Transection of the medial forebrain bundle caused apoptosis of dopamine neurons in the rat substantia nigra. Immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of microglia was rapid and OX-6 (MHC-II marker)-positive and ED1 (lysosomal phagocytic marker)-positive microglia were apposed to structurally intact tyrosine hydroxylase-positive dopamine neurons, indicating microglial phagocytosis of degenerating dopamine neurons. The occurrence of microglial phagocytosis at early stages of apoptosis may indicate the evolution of apoptosis into an irreversible state. Alternatively, interventions that suppress early activation of microglia might lead to novel mechanisms for neuron protection..
Department
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine
Citation
Cellular and Molecular Neurobiology, Vol.23(4-5) : 551-560, 2003
Type
Article
ISSN
0272-4340
DOI
10.1023/A:1025024129946
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35385
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