Association of cardio-ankle vascular index with diastolic heart function in hypertensive patients

Hyungseop KimHye-Soon KimHyuck-Jun YoonHyoung-Seob ParkYun-Kyeong ChoChang-Wook NamSeung-Ho HurYoon-Nyun KimKwon-Bae Kim
Dept. of Internal Medicine (내과학)
Issue Date
Clinical and Experimental Hypertension, Vol.36(4) : 200-205, 2014
Arterial stiffness is an important risk factor of impaired left ventricular (LV) diastolic function as well as systolic dysfunction. The cardio-ankle vascular index (CAVI) and the ambulatory arterial stiffness index (AASI) can evaluate arteriosclerosis. We analyzed the relationship between arterial stiffness and diastolic function, and then compared the two methodologies to assess which method could serve as a more informative tool for diastology. In total, 136 patients with hypertension underwent 24-h ambulatory blood pressure monitoring (ABPM) and echocardiography including ventricular arterial coupling (VAC). Arterial stiffness was estimated using both CAVI and AASI derived from ABPM. Patients were classified into LV diastolic dysfunction and normal function groups. Those with diastolic dysfunction had a higher CAVI and AASI. Aside from LV torsion, mitral inflow parameters, tissue Doppler velocities and VAC showed a significantly greater association with CAVI, relative to AASI. The receiver operating characteristic curve analysis revealed that CAVI [area under the curve (AUC)===0.869, p=<=0.001] provided significantly more favorable accuracy for diastolic dysfunction compared with AASI (AUC===0.672, p===0.004). Multiple logistic regression analyses showed that CAVI [Odds ratio (OR)===5.1, p===0.009] had a greater association with diastolic dysfunction, relative to age, systolic blood pressure or AASI (OR===1.4, p===0.043). This study indicates that CAVI clinically provides diastolic functional information much better in hypertensive patients than AASI. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
김형섭; 김혜순; 윤혁준; 박형섭; 조윤경; 남창욱; 허승호; 김윤년; 김권배
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