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Association of cardio-ankle vascular index with diastolic heart function in hypertensive patients

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Author(s)
김형섭김혜순윤혁준박형섭조윤경남창욱허승호김윤년김권배
Alternative Author(s)
Kim, Hyung SeopKim, Hye SoonYoon, Hyuck JunPark, Hyoung SeobCho, Yun KyeongNam, Chang WookHur, Seung HoKim, Yoon NyunKim, Kwon Bae
Publication Year
2014
Abstract
Arterial stiffness is an important risk factor of impaired left ventricular (LV) diastolic function as well as systolic dysfunction. The cardio-ankle vascular index (CAVI) and the ambulatory arterial stiffness index (AASI) can evaluate arteriosclerosis. We analyzed the relationship between arterial stiffness and diastolic function, and then compared the two methodologies to assess which method could serve as a more informative tool for diastology. In total, 136 patients with hypertension underwent 24-h ambulatory blood pressure monitoring (ABPM) and echocardiography including ventricular arterial coupling (VAC). Arterial stiffness was estimated using both CAVI and AASI derived from ABPM. Patients were classified into LV diastolic dysfunction and normal function groups. Those with diastolic dysfunction had a higher CAVI and AASI. Aside from LV torsion, mitral inflow parameters, tissue Doppler velocities and VAC showed a significantly greater association with CAVI, relative to AASI. The receiver operating characteristic curve analysis revealed that CAVI [area under the curve (AUC)===0.869, p=<=0.001] provided significantly more favorable accuracy for diastolic dysfunction compared with AASI (AUC===0.672, p===0.004). Multiple logistic regression analyses showed that CAVI [Odds ratio (OR)===5.1, p===0.009] had a greater association with diastolic dysfunction, relative to age, systolic blood pressure or AASI (OR===1.4, p===0.043). This study indicates that CAVI clinically provides diastolic functional information much better in hypertensive patients than AASI. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Clinical and Experimental Hypertension, Vol.36(4) : 200-205, 2014
Type
Article
ISSN
1064-1963
DOI
10.3109/10641963.2013.804544
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35448
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