An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas
- 박종욱; 권택규; 김신; 황일선; 백성규; 이재호
- Alternative Author(s)
- Park, Jong Wook; Kwon, Taeg Kyu; Kim, Shin; Hwang, Il Seon; Baek, Seong Kyu; Lee, Jae Ho
- Publication Year
- MicroRNAs (miRNAs) regulate gene expression
through degradation and/or translational repression of
target mRNAs. Dysregulations in the miRNA machinery
may be involved in carcinogenesis of colorectal cancer
(CRC). The purpose of the current study was to evaluate
the DiGeorge syndrome critical region gene 8 (DGCR8)
and argonaute 2 (AGO2) mRNA expression in CRC and to
evaluate the value of clinical parameters on their expression.
We investigated the mRNA expressions of DGCR8
and AGO2 in 60 CRC tissues and adjacent histologically
non-neoplastic tissues by using quantitative real-time PCR.
Our study revealed that the mRNA expression level of
DGCR8 is up-regulated in CRC. However, AGO2 mRNA
expression was not significantly altered in CRC tissues.
Neither DGCR8 nor AGO2 mRNA expression level was
not associated with any clinical parameters, including age,
tumor stage, CEA titer, and BMI in CRC cases. However,
the mRNA expression levels of DGCR8 and AGO2 were
positively correlated to each other. This study demonstrated
for the first time that the DGCR8 mRNA expression
level was up-regulated in CRC, suggesting its important
role in pathobiology of colorectal carcinogenesis.
Keywords MicroRNA biogenesis Colorectal cancer
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