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An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas

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Author(s)
Bora KimJae-ho LeeJong Wook ParkTaeg Kyu KwonSeong Kyu BaekIlseon HwangShin Kim
Keimyung Author(s)
Park, Jong WookKwon, Taeg KyuKim, ShinHwang, Il SeonBaek, Seong KyuLee, Jae Ho
Department
Dept. of Immunology (면역학)
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Dept. of Anatomy (해부학)
Journal Title
Clinical and Experimental Medicine
Issued Date
2014
Volume
14
Issue
3
Abstract
MicroRNAs (miRNAs) regulate gene expression
through degradation and/or translational repression of
target mRNAs. Dysregulations in the miRNA machinery
may be involved in carcinogenesis of colorectal cancer
(CRC). The purpose of the current study was to evaluate
the DiGeorge syndrome critical region gene 8 (DGCR8)
and argonaute 2 (AGO2) mRNA expression in CRC and to
evaluate the value of clinical parameters on their expression.
We investigated the mRNA expressions of DGCR8
and AGO2 in 60 CRC tissues and adjacent histologically
non-neoplastic tissues by using quantitative real-time PCR.
Our study revealed that the mRNA expression level of
DGCR8 is up-regulated in CRC. However, AGO2 mRNA
expression was not significantly altered in CRC tissues.
Neither DGCR8 nor AGO2 mRNA expression level was
not associated with any clinical parameters, including age,
tumor stage, CEA titer, and BMI in CRC cases. However,
the mRNA expression levels of DGCR8 and AGO2 were
positively correlated to each other. This study demonstrated
for the first time that the DGCR8 mRNA expression
level was up-regulated in CRC, suggesting its important
role in pathobiology of colorectal carcinogenesis.
Keywords MicroRNA biogenesis Colorectal cancer
DGCR8 AGO2
Keimyung Author(s)(Kor)
박종욱
권택규
김신
황일선
백성규
이재호
Publisher
School of Medicine
Citation
Bora Kim et al. (2014). An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas. Clinical and Experimental Medicine, 14(3), 331–336.
Type
Article
ISSN
1591-8890
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35449
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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