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IMPACT OF CHILDHOOD ADVERSITY ON THE COURSE AND SUICIDALITY OF DEPRESSIVE DISORDERS: THE CRESCEND STUDY

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Author(s)
정성원
Alternative Author(s)
Jung, Sung Won
Publication Year
2013
Abstract
Objective: The impact of childhood adversity persists across the life course. This
study aimed to investigate the associations of childhood adversity with the course,
suicidality, and treatment outcomes of depressive disorders.
Method: A total of
919 people with depressive disorders were recruited. Childhood adversities (≤12
years old) were ascertained using a checklist, in sexual abuse, physical abuse
by parents, and separation of parents. Various assessment scales were adminis-
tered at baseline and over 12 weeks of antidepressants treatment.
Results: All
three forms of childhood adversity were associated with an increased likelihood
of experiencing more current stressful events. Scores on the Beck Depression
Inventory and Hamilton Anxiety Rating Scale were significantly higher in par-
ticipants with a history of sexual abuse. Scores on the Beck Depression Inventory,
Hamilton Depression Rating Scale, and Perceived Stress Scale were significantly
higher, and scores on the WHO Quality of life instrument were significantly
lower in participants with a history of physical abuse by parents. They were
more likely to receive augmentation and combination treatment after the ini-
tial antidepressant treatment, whereas overall response rates to treatment did not
differ. Scores on the Beck Scale for suicide ideation were significantly higher after
treatment and/or at baseline in patients with sexual or physical abuse. Physical
illness was more prevalent in individuals with physical abuse by parents or sep-
aration of parents.
Conclusions: Depressive patients with a history of childhood
adversities had more severe and chronic forms of depression with high suicidality.
More intensive treatment with particular clinical attention is indicated for this
special population. Depression and Anxiety 30:965–974, 2013
Department
Dept. of Psychiatry (정신건강의학)
Publisher
School of Medicine
Citation
Depression and Anxiety, Vol.30(10) : 965-974, 2013
Type
Article
ISSN
1091-4269
DOI
10.1002/da.22088
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35551
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