IMPACT OF CHILDHOOD ADVERSITY ON THE COURSE AND SUICIDALITY OF DEPRESSIVE DISORDERS: THE CRESCEND STUDY

Authors
Sung-Wan KimHee-Ju KangSeon-Young KimJae-Min KimJin-Sang YoonSung-Won JungMin-Soo LeeHyeon-Woo YimTae-Youn Jun
Department
Dept. of Psychiatry (정신건강의학)
Issue Date
2013
Citation
Depression and Anxiety, Vol.30(10) : 965-974, 2013
ISSN
1091-4269
Abstract
Objective: The impact of childhood adversity persists across the life course. This study aimed to investigate the associations of childhood adversity with the course, suicidality, and treatment outcomes of depressive disorders. Method: A total of 919 people with depressive disorders were recruited. Childhood adversities (≤12 years old) were ascertained using a checklist, in sexual abuse, physical abuse by parents, and separation of parents. Various assessment scales were adminis- tered at baseline and over 12 weeks of antidepressants treatment. Results: All three forms of childhood adversity were associated with an increased likelihood of experiencing more current stressful events. Scores on the Beck Depression Inventory and Hamilton Anxiety Rating Scale were significantly higher in par- ticipants with a history of sexual abuse. Scores on the Beck Depression Inventory, Hamilton Depression Rating Scale, and Perceived Stress Scale were significantly higher, and scores on the WHO Quality of life instrument were significantly lower in participants with a history of physical abuse by parents. They were more likely to receive augmentation and combination treatment after the ini- tial antidepressant treatment, whereas overall response rates to treatment did not differ. Scores on the Beck Scale for suicide ideation were significantly higher after treatment and/or at baseline in patients with sexual or physical abuse. Physical illness was more prevalent in individuals with physical abuse by parents or sep- aration of parents. Conclusions: Depressive patients with a history of childhood adversities had more severe and chronic forms of depression with high suicidality. More intensive treatment with particular clinical attention is indicated for this special population. Depression and Anxiety 30:965–974, 2013
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35551
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
Keimyung Author(s)
정성원
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22088
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