INFLUENCE OF THE SEROTONIN TRANSPORTER PROMOTER GENE POLYMORPHISM ON SUSCEPTIBILITY TO POSTTRAUMATIC STRESS DISORDER

Authors
Heon-Jeong LeeMin-Soo LeeRhee-Hun KangHyun KimSoon-Duck KimBaik-Seok KeeYoung Hoon KimYong-Ku KimJung Bum KimByung Kil YeonKang Seob OhByung-Hoon OhJin-Sang YoonChul LeeHan Yong JungIk-Seung CheeIn Ho Paik
Department
Dept. of Psychiatry (정신건강의학)
Issue Date
2005
Citation
Depression and Anxiety, Vol.21(3) : 135-139, 2005
ISSN
1091-4269
Abstract
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible as sociation between the serotonin- transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case–control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in norm al controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are requ ired into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment. Depression and Anxiety 21:135–139, 2005
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35552
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
Keimyung Author(s)
김정범
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/da.20064
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