INFLUENCE OF THE SEROTONIN TRANSPORTER
PROMOTER GENE POLYMORPHISM ON SUSCEPTIBILITY
TO POSTTRAUMATIC STRESS DISORDER
- Alternative Author(s)
- Kim, Jung Bum
- Publication Year
- Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by
behavioral, physiologic, and hormonal alterations. The etiology of PTSD is
unknown, although exposure to a traumatic event constitutes a necessary, but
not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD.
The present study examined the possible as sociation between the serotonin-
transporter-linked polymorphic region (SERTPR) and PTSD. The genotype
and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and
197 unrelated healthy controls using a case–control design. The frequency of the
s/s genotype was significantly higher in PTSD patients than in norm al controls.
These findings suggest that the SERTPR s/s genotype is one of the genetic factors
for the susceptibility to PTSD. Further investigations are requ ired into the
influence of gene polymorphisms on the biological mechanisms of PTSD, its
clinical expression, and its response to treatment. Depression and Anxiety
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