Genome-Wide Association
Meta-analysis Identifies Novel
Variants Associated With
Fasting Plasma Glucose in
East Asians
- Affiliated Author(s)
- 신동훈
- Alternative Author(s)
- Shin, Dong Hoon
- Journal Title
- Diabetes
- ISSN
- 0012-1797
- Issued Date
- 2015
- Abstract
- Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
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