Anti-anaerobic coverage is not necessary for Klebsiella pneumoniae liver
abscess: a propensity score–matched cohort study
- Affiliated Author(s)
- 김현아; 류성열
- Alternative Author(s)
- Kim, Hyun Ah; Ryu, Seong Yeol
- Journal Title
- Diagnostic Microbiology and Infectious Disease
- ISSN
- 0732-8893
- Issued Date
- 2015
- Abstract
- Although most Klebsiella pneumoniae liver abscesses have been reported to be monomicrobial, clinical outcomes
have not been compared between antimicrobial therapy with and without anti-anaerobic coverage. A propensity
score–matched cohort study was conducted using the 731 cases of K. pneumoniae liver abscess. Clinical outcomes
were compared between a group discontinuing anti-anaerobic agents after K. pneumoniae identification and a
group continuing. A total of 170 cases were matched at a 1:1 ratio using their propensity to discontinue antianaerobic
agents. The McNemar's test showed no difference in mortality rates (1.8% for discontinuation versus
2.3% for continuation; P =1.00) or relapse (1.8% versus 2.9%; P= 0.73) between groups. Early discontinuation of
anti-anaerobic agents had no association with treatment failure by means of the generalized estimating equation
model (odds ratio 0.48; P=0.14) and the Kaplan–Meier method (P=0.85) in matched groups. Early discontinuation
of anti-anaerobic agents does not affect the clinical outcomes of patients with K. pneumoniae liver abscess.
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