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Anti-anaerobic coverage is not necessary for Klebsiella pneumoniae liver abscess: a propensity score–matched cohort study

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Author(s)
Hyun Ah KimDoo Ryeon ChungJoon-Sup YeomHyun Kyun KiHae Suk CheongJun Seong SonJin Seo LeeSoo-youn MoonSeung Soon LeeJeong-A LeeKyung-Hwa ParkSeung-Ji KangSook-In JungShin-Woo KimHyun Ha ChangSeong Yeol RyuKi Tae KwonChisook MoonYu Mi WiSang Taek HeoMi Kyong JoungCheol-In KangKyong Ran PeckJae-Hoon Song
Keimyung Author(s)
Kim, Hyun AhRyu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diagnostic Microbiology and Infectious Disease
Issued Date
2015
Volume
81
Issue
1
Abstract
Although most Klebsiella pneumoniae liver abscesses have been reported to be monomicrobial, clinical outcomes
have not been compared between antimicrobial therapy with and without anti-anaerobic coverage. A propensity
score–matched cohort study was conducted using the 731 cases of K. pneumoniae liver abscess. Clinical outcomes
were compared between a group discontinuing anti-anaerobic agents after K. pneumoniae identification and a
group continuing. A total of 170 cases were matched at a 1:1 ratio using their propensity to discontinue antianaerobic
agents. The McNemar's test showed no difference in mortality rates (1.8% for discontinuation versus
2.3% for continuation; P =1.00) or relapse (1.8% versus 2.9%; P= 0.73) between groups. Early discontinuation of
anti-anaerobic agents had no association with treatment failure by means of the generalized estimating equation
model (odds ratio 0.48; P=0.14) and the Kaplan–Meier method (P=0.85) in matched groups. Early discontinuation
of anti-anaerobic agents does not affect the clinical outcomes of patients with K. pneumoniae liver abscess.
Keimyung Author(s)(Kor)
김현아
류성열
Publisher
School of Medicine
Citation
Hyun Ah Kim et al. (2015). Anti-anaerobic coverage is not necessary for Klebsiella pneumoniae liver
abscess: a propensity score–matched cohort study. Diagnostic Microbiology and Infectious Disease, 81(1), 60–65. doi: 10.1016/j.diagmicrobio.2014.10.002
Type
Article
ISSN
0732-8893
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0732889314004106?via%3Dihub
DOI
10.1016/j.diagmicrobio.2014.10.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35587
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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