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Cardiodynamics and Infarct Size in Regional and Global Ischemic Isolated Heart Model: Comparison of 1 Hour and 2 Hours Reperfusion

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Affiliated Author(s)
이미영
Alternative Author(s)
Lee, Mi Young
Journal Title
Korean Circulation Journal
ISSN
1738-5520
Issued Date
2012
Keyword
HeartMyocardial ischemiaMyocardial infarctionMyocardial reperfusion
Abstract
Background and Objectives: We investigated whether 1 hour reperfusion is enough to assess cardiodynamics and infarct size in both regional ischemia (RI) and global ischemia (GI) in isolated rat heart models. Materials and Methods: Hearts were randomly assigned to one of the following groups (each n=14): 1) Sham hearts for 1 hour; 2) Sham hearts for 2 hours; 3) 30 minutes RI followed by 1 hour reperfusion; 4) 30 minutes of RI followed by 2 hours reperfusion; 5) 30 minutes GI followed by 1 hour reperfusion; and 6) 30 minutes GI followed by 2 hours reperfusion. Results: There were no significant differences in infarct size between 1 hour and 2 hours reperfusion in both RI and GI. Left ventricular developed pressure was significantly decreased at both 1 hour and 2 hours reperfusion in groups of RI and GI compared to baseline (p<0.01). Rate-pressure product and +dP/dtmax also significantly decreased compared to baseline level at both 1 hour and 2 hours reperfusion in groups of RI and GI (p<0.05). Conclusion: There was no significant difference in infarct size between 1 hour and 2 hours reperfusion in groups of RI and GI. Cardiodynamic variables measured at 1 hour and 2 hours reperfusion significantly decreased compared to baseline level. Our data suggests that reperfusion of 1 hour is sufficient to assess cardiodynamics in both regional and global ischemic isolated hearts model.
Department
Dept. of Preventive Medicine (예방의학)
Institute for Medical Science (의과학연구소)
Publisher
School of Medicine
Citation
June Hong Kim et al. (2012). Cardiodynamics and Infarct Size in Regional and Global Ischemic Isolated Heart Model: Comparison of 1 Hour and 2 Hours Reperfusion. Korean Circulation Journal, 42(9), 600–605. doi: 10.4070/kcj.2012.42.9.600
Type
Article
ISSN
1738-5520
DOI
10.4070/kcj.2012.42.9.600
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36041
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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