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Effect of Overexpression of Glucose-Regulated Protein 78 and Bcl-2 on Recurrence and Survival in Patients With Ureter Tumors

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Author(s)
하지용김병훈박철희김천일최미선
Alternative Author(s)
Ha, Ji YongKim, Byung HoonPark, Choal HeeKim, Chun IlChoe, Mi Sun
Publication Year
2013
Keyword
Bcl-2GRP78Urothelial cell carcinoma
Abstract
Purpose: The utility of the expression of glucose-regulated protein 78 (GRP78) in the evaluation of prognosis depends on the type of tumor. Hence, we aimed to examine the impact of expression of GRP78 and Bcl-2, which are used in the existing prognostic evaluation of ureter tumors, in the evaluation of recurrence and survival rates of ureter tumors. Materials and Methods: In 53 patients who had undergone radical nephroureterectomy for a ureter tumor from March 2002 to March 2012, age, sex, T stage, nuclear grade, bladder recurrence, and survival rate were analyzed at the time of the patient's surgery depending on the extent of immunohistochemical expression of GRP78 and
Bcl-2. Results: GRP78 was overexpressed in 25 patients (47.2%). When GRP78 was overexpressed, there was a high T stage (p=0.001) and nuclear grade (p=0.007) and a lot of bladder recurrence (40.0%, p=0.034). Bcl-2 was overexpressed in 16 patients (30.1%), and there were no significant associations with any risk factors (p>0.05, respectively). In the multivariate analysis regarding bladder recurrence, the recurrence rate was higher with higher pT stage (p=0.048) and when GRP78 (p=0.033) was overexpressed. In the Kaplan-Meier survival analysis, although the survival rate was significantly lower in the group in which GRP78 was overexpressed (p=0.03), there was no correlation between Bcl-2 overexpression and survival rate (p=0.07). Conclusions: Patients with ureter tumors who had overexpression of GRP78 had a high T stage and nuclear grade, a lot of bladder recurrence, and a low survival rate. Therefore, if GRP78 is overexpressed in ureter tumor patients, active postoperative follow-up should be carried out.
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Korean Journal of Urology, Vol.54(10) : 671-676, 2013
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2013.54.10.671
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36257
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