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Effect of Overexpression of Glucose-Regulated Protein 78 and Bcl-2 on Recurrence and Survival in Patients With Ureter Tumors

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Author(s)
Chang Hyun ParkMi Sun ChoiJi Yong HaByung Hoon KimChoal Hee ParkChun Il Kim
Keimyung Author(s)
Ha, Ji YongKim, Byung HoonPark, Choal HeeKim, Chun IlChoe, Mi Sun
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Urology
Issued Date
2013
Volume
54
Issue
10
Keyword
Bcl-2GRP78Urothelial cell carcinoma
Abstract
Purpose: The utility of the expression of glucose-regulated protein 78 (GRP78) in the evaluation of prognosis depends on the type of tumor. Hence, we aimed to examine the impact of expression of GRP78 and Bcl-2, which are used in the existing prognostic evaluation of ureter tumors, in the evaluation of recurrence and survival rates of ureter tumors. Materials and Methods: In 53 patients who had undergone radical nephroureterectomy for a ureter tumor from March 2002 to March 2012, age, sex, T stage, nuclear grade, bladder recurrence, and survival rate were analyzed at the time of the patient's surgery depending on the extent of immunohistochemical expression of GRP78 and
Bcl-2. Results: GRP78 was overexpressed in 25 patients (47.2%). When GRP78 was overexpressed, there was a high T stage (p=0.001) and nuclear grade (p=0.007) and a lot of bladder recurrence (40.0%, p=0.034). Bcl-2 was overexpressed in 16 patients (30.1%), and there were no significant associations with any risk factors (p>0.05, respectively). In the multivariate analysis regarding bladder recurrence, the recurrence rate was higher with higher pT stage (p=0.048) and when GRP78 (p=0.033) was overexpressed. In the Kaplan-Meier survival analysis, although the survival rate was significantly lower in the group in which GRP78 was overexpressed (p=0.03), there was no correlation between Bcl-2 overexpression and survival rate (p=0.07). Conclusions: Patients with ureter tumors who had overexpression of GRP78 had a high T stage and nuclear grade, a lot of bladder recurrence, and a low survival rate. Therefore, if GRP78 is overexpressed in ureter tumor patients, active postoperative follow-up should be carried out.
Keimyung Author(s)(Kor)
하지용
김병훈
박철희
김천일
최미선
Publisher
School of Medicine
Citation
Chang Hyun Park et al. (2013). Effect of Overexpression of Glucose-Regulated Protein 78 and Bcl-2 on Recurrence and Survival in Patients With Ureter Tumors. Korean Journal of Urology, 54(10), 671–676. doi: 10.4111/kju.2013.54.10.671
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2013.54.10.671
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36257
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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