투명 신세포암의 예후인자로서의 Caveolin-1과 Ki-67의 면역조직화학적 발현

Abstract

Purpose: Caveolin-1 is proposed to represent a novel tumor suppressor protein and expression of recombinant caveolin-1 is sufficient to restrict the growth potential of transformed cells isolated from primary tumors of the breast, lung, and ovaries. We examined the relationship of caveolin-1 and Ki-67 expression to clinicopathological variables in patients with clear cell carcinomas of the kidney. Materials and Methods: We examined caveolin-1 and Ki-67 expression in 119 clear cell carcinomas of the kidney using immunohistochemistry, and analyzed its relationship with tumor size, nuclear grade, TNM stage, vascular invasion, capsular invasion, metastasis, and metachronous metastasis were investigated. Results: Of the 119 tumors analyzed, lymph node and distant metastasis (synchronous metastasis: 7, metachronous metastasis: 15) occurred in 3 and 22 cases, respectively. Caveolin-1 expression correlated with the T stage (p=0.004), TNM stage (p=0.013), metastasis (p=0.013), and metachronous metastasis (p=0.001). Ki-67 expression correlated with the T stage (p=0.041), nuclear grade (p=0.011), and vascular invasion (p=0.043). Caveolin-1 and Ki-67 expression showed similar changes, but there was no statistical significance (p=0.050). Conclusions: Caveolin-1 is expressed frequently in patients with metachronous metastasis, and may predict metastasis after surgery for clear cell carcinoma of the kidney.