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투명 신세포암의 예후인자로서의 Caveolin-1과 Ki-67의 면역조직화학적 발현

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Author(s)
김병훈김천일박철희
Keimyung Author(s)
Kim, Byung HoonKim, Chun IlPark, Choal Hee
Department
Dept. of Urology (비뇨의학)
Journal Title
Korean Journal of Urology
Issued Date
2008
Volume
49
Issue
2
Keyword
Clear cell renal carcinomaCaveolin 1Ki-67 antigen
Abstract
Purpose: Caveolin-1 is proposed to represent a novel tumor suppressor protein and expression of recombinant caveolin-1 is sufficient to restrict the growth potential of transformed cells isolated from primary tumors of the breast, lung, and ovaries. We examined the relationship of caveolin-1 and Ki-67 expression to clinicopathological variables in patients with clear cell carcinomas of the kidney. Materials and Methods: We examined caveolin-1 and Ki-67 expression in 119 clear cell carcinomas of the kidney using immunohistochemistry, and analyzed its relationship with tumor size, nuclear grade, TNM stage, vascular invasion, capsular invasion, metastasis, and metachronous metastasis
were investigated. Results: Of the 119 tumors analyzed, lymph node and distant metastasis (synchronous metastasis: 7, metachronous metastasis: 15) occurred in 3 and 22 cases, respectively. Caveolin-1 expression correlated with the T stage (p=0.004), TNM stage (p=0.013), metastasis (p=0.013), and metachronous metastasis (p=0.001). Ki-67 expression correlated with the T stage (p=0.041), nuclear grade (p=0.011), and vascular invasion (p=0.043). Caveolin-1 and Ki-67 expression showed similar changes, but there was no statistical significance (p=0.050).
Conclusions: Caveolin-1 is expressed frequently in patients with metachronous metastasis, and may predict metastasis after surgery for clear
cell carcinoma of the kidney.
Alternative Title
Caveolin-1 and Ki-67 Expression as Prognostic Factors in Clear Cell Carcinoma of the Kidney
Keimyung Author(s)(Kor)
김병훈
김천일
박철희
Publisher
School of Medicine
Citation
김병훈 et al. (2008). 투명 신세포암의 예후인자로서의 Caveolin-1과 Ki-67의 면역조직화학적 발현. Korean Journal of Urology, 49(2), 99–106. doi: 10.4111/kju.2008.49.2.99
Type
Article
ISSN
0494-4747
DOI
10.4111/kju.2008.49.2.99
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36276
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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