Skin hydration and collagen synthesis of AF-343 in HS68 cell line and NC/NGa mice by filaggrin expression and suppression of matrix metalloproteinase

Authors
Hyun Kyu KimYoung-Jin ChunJae-We ChoYeon-su JeongJiwon HanMin Young KimBeom Joon KimKi Moon ParkJong Keun KimJae Hyun KimSoo-Muk Cho
Department
Dept. of Dermatology (피부과학)
Issue Date
2011
Citation
Toxicological Research, Vol.27(4) : 225-229, 2011
ISSN
1976-8257
Abstract
Extract of Taraxacum platycarpum (AF-343) has been reported to have several biological properties such as skin hydration and anti-inflammatory effects. Although clinical evidences of skin hydration and anti-inflammatory effect were proven in clinical trial, precise mechanism of skin hydration was not fully understood yet. In this study, we have focused skin hydration mechanism related filaggrin, collagen, and matrix metalloproteinase (MMP) in vitro and animal study. Herein, skin hydration mechanism of AF-343 is due to recovery of filaggrin in mice model and increased production of collagen with suppression of matrix MMP in vitro fibroblast cell line.
Keywords
Taraxacum platycarpumType I collagenMMP-1Smad2/3
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36357
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
Keimyung Author(s)
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