Safety Evaluation of Topical Valproate Application

Authors
Sun Young ChoiSong Yi SeopMoo Yeol HyunKwang Ho YooBeom Joon KimMyeung Nam KimJae-We Cho
Department
Dept. of Dermatology (피부과학)
Issue Date
2013
Citation
Toxicological Research, Vol.29(2) : 87-90, 2013
ISSN
1976-8257
Abstract
The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells. We then performed clinical patch test and skin irritation test through transdermal drug delivery with the help of microneedle rollers. No significant findings were obtained in the clinical patch test. In the skin irritation test, only 1 patient showed erythema at 1 hr, but the irritation reaction faded away within a few hours. Erythema and edema were not observed at 24 hr. We concluded that VPA has minimal potential to elicit skin irritation. Therefore, we consider that VPA can safely be applied to human skin.
Keywords
ValproateSkin toxicity
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36358
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
Keimyung Author(s)
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