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Safety Evaluation of Topical Valproate Application

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Author(s)
Sun Young ChoiSong Yi SeopMoo Yeol HyunKwang Ho YooBeom Joon KimMyeung Nam KimJae-We Cho
Keimyung Author(s)
Cho, Jae We
Department
Dept. of Dermatology (피부과학)
Journal Title
Toxicological Research
Issued Date
2013
Volume
29
Issue
2
Keyword
ValproateSkin toxicity
Abstract
The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells. We then performed clinical patch test and skin irritation test through transdermal drug delivery with the help of microneedle rollers. No significant findings were obtained in the clinical patch test. In the skin irritation test, only 1 patient showed erythema at 1 hr, but the irritation reaction faded away within a few hours. Erythema and edema were not observed at 24 hr. We concluded that VPA has minimal potential to elicit skin irritation. Therefore, we consider that VPA can safely be applied to human skin.
Keimyung Author(s)(Kor)
조재위
Publisher
School of Medicine
Citation
Sun Young Choi et al. (2013). Safety Evaluation of Topical Valproate Application. Toxicological Research, 29(2), 87–90. doi: 10.5487/TR.2013.29.2.087
Type
Article
ISSN
1976-8257
DOI
10.5487/TR.2013.29.2.087
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36358
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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