양극성 장애 아형의 임상적 특성

Abstract

Objectives ： This study evaluated the clinical characteristics in subtypes of mania according to the degree of concomitant depressive symptoms. Methods : The subjects were 60 DSM-IV manic or mixed type patients, who were classified into three groups, i.e. pure mania, mixed mania, and mania with mild depression on the basis of depressive symptoms. Three groups were compared in demographic characteristics, family history of mental illness, clinical characteristics, and psychopathology at time of admission. Results ： The frequencies of subtypes were pure mania group 30 patients(50%), mixed mania group 15 patients(25%), and mania with mild depression 15 patients(25%). There were no significant differences in age at admission, sex distribution and family history of mental illness among three groups. Mild depression group had more hospitalization than pure mania group. Pure mania group had better inter-episodic remission level than mixed group. Pure mania group had longer duration from previous episode to current episode than other two groups. There were no significant differences in severity and frequency of nine manic symptoms among three groups, but mood-congruent delusion was more frequent and severe in mixed mania group. Conclusion : The results of this study revealed that manic patients with concomitant depressive symptoms had different clinical characteristics from pure mania group regardless of the severity of depressive symptoms, and mild depression group had similar clinical characteristics to mixed mania group rather than to pure mania group. Further research is necessary for diagnostic classification of manic patients with mild depressive symptoms.