제 2 형 당뇨병 동물 모델인 OLETF ( Otsuka Long - Evans Tokushima Fatty ) 쥐에서 a - lipoic acid 에 의한 혈관기능장애의 회복

Abstract

Objective : It has been suggested that increased oxidative stress contributes to atherogenesis and endothelial dysfunction. Methods : OLETF rats at 12 weeks of age were divided into two groups, and were given diet with(n=6) or without(n=11) 5% a-lipoic acid. Results : Endothelium-dependent and independent vasorelaxation was impaired in OLETE rats. Conclusion : OLETE rats showed impaired responsiveness in endothelium-dependent and endothelium-independent vasorelaxation and decreased urinary NO excretion.