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활성 신경교세포의 Nitric Oxide 생성증가에 의한 망간의 세포독성

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Author(s)
김성진서준영배재훈정인성이미영신동훈
Publication Year
2003
Keyword
Nitric oxideManganeseCytotoxicityGliaLPSManganesel
Abstract
Background : Glial cells are generally known to support normal neuronal functions tightly regulating the extracellular environment and providing energy substrates such as glucose. Therefor, dysfunction or loss of glial cells will lead to neuonal death. Since manganese (Mn2+) is known to be sequestered in glial cells, we investigated whether nitric oxide (NO) production in the activated glial cells is potentiated by Manganese and the relationship between increased NO production and Manganese cytotoxicity of glial cells.
Methods : Manganese toxicity was assessed by morphological examination and by measuring the release of lactate dehydrogenase.
Result : Neither a LPS nor a MnCl2 altered the viability of glial cells. A 24 hr stimulation both LPS and MnCl2, however, markedly potential the manganese-induced death of glial cells.
Conclusion : It is concluded that manganese could induce sustained production of neurotoxic nitric oxide by the activated glial ceels and manganese-induced cytotoxicity is partially mediated by potentiation of LPS- induced nitric oxide in the glial cell culture model.
Alternative Title
Manganese Cytotoxicity Mediated by Potentiation of Nitric Oxide Production in Activated Glial Cell
Department
Dept. of Emergency Medicine (응급의학)
Dept. of Physiology (생리학)
Dept. of Preventive Medicine (예방의학)
Brain Research Institute (뇌연구소)
Publisher
School of Medicine
Citation
항공우주의학, Vol.13(4) : 190-197, 2003
Type
Article
ISSN
1738-2548
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/37201
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