자궁경부암에서 종양억제 유전자 p53 생성물의 발현

Abstract

the nuclear accumulation of p53 protein is known to correspond with mutation of the p53 tumor supressor gene. to investigate the relationship between clinico-pathologic features and expression of p53 muta tions, 65 cases of primary cervical carcinoma were analysed by an immunohistochemical method using monoclonal antibody of p53. Immunostaining demonstrated various nuclear stinings of cancer cells in 48.4% of squamous cell carcinoma(51.9% in large cell carcinoma and 25.0% in small cell carcinomas) and 23.5% of adenocarcinoma.(p<0.05) No differences in clinical stage and p53 positivity were found. There was no significant correlation between p53 positive cases and status of recurrence. This data suggests that p53 mutation plays an important role in carcinogenesis of the cervical cancer. the nuclear accumulation of p53 protein is not correlated with the disease progression and prognosis.