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자궁경부암에서 종양억제 유전자 p53 생성물의 발현

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Author(s)
권경익이태성이정호차순도이상숙서영욱
Keimyung Author(s)
Lee, Sang SookLee, Tae SungRhee, Jeong HoCha, Soon DoSuh, Young Wook
Department
Dept. of Pathology (병리학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Journal of Gynecologic Oncology
Issued Date
1994
Volume
5
Issue
4
Abstract
the nuclear accumulation of p53 protein is known to correspond with mutation of the p53
tumor supressor gene.
to investigate the relationship between clinico-pathologic features and expression of p53 muta
tions, 65 cases of primary cervical carcinoma were analysed by an immunohistochemical method
using monoclonal antibody of p53.
Immunostaining demonstrated various nuclear stinings of cancer cells in 48.4% of squamous
cell carcinoma(51.9% in large cell carcinoma and 25.0% in small cell carcinomas) and 23.5% of
adenocarcinoma.(p<0.05) No differences in clinical stage and p53 positivity were found.
There was no significant correlation between p53 positive cases and status of recurrence.
This data suggests that p53 mutation plays an important role in carcinogenesis of the cervical
cancer. the nuclear accumulation of p53 protein is not correlated with the disease progression and
prognosis.
Alternative Title
Expression of the mutant p53 gene in the careinoma of the cervix uteri
Keimyung Author(s)(Kor)
이상숙
이태성
이정호
차순도
서영욱
Publisher
School of Medicine
Citation
권경익 et al. (1994). 자궁경부암에서 종양억제 유전자 p53 생성물의 발현. Journal of Gynecologic Oncology, 5(4), 23–28.
Type
Article
ISSN
2005-0380
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37463
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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