신장 이식에서 일차 면역억제제로서 Tacrolimus의 효과
- 김현철; 박성배; 한승엽; 황은아; 전동석; 김형태; 조원현; 박철희
- Alternative Author(s)
- Kim, Hyun Chul; Park, Sung Bae; Han, Seung Yeup; Jeon, Dong Seok; Hwang, Eun Ah; Kim, Hyoung Tae; Cho, Won Hyun; Park, Choal Hee
- Issued Date
- Purpose: Tacrolimus (FK-506) represents a major advance in the prevention of rejection following solid organ transplantation. Previous clinical trials in Japan, Europe, and the US suggest that tacrolimus is an effective primary immunosuppressive agent in kidney transplantation. This prospective, non-randomized single center study was done to confirmed the efficacy of tacrolimus in kidney transplantation. Methods: A total of 50 renal transplant recipients who followed-up at least one year after transplantation was included in this study. Thirty six cases (72%) recived triple drug therapy consists of tacrolimus, mycophenolate mofetil (MMF), and low dose steroid. Results: The overall incidence of acute rejection was 10%, alt episodes of Section were treated effectively with steroid pulse therapy. The incidence of treatment failure was six percent. One and two year graft survival were 98% and 96%, respectively. Adverse effects of tacrolimus therapy included tremor of the hand (56%), diantiea (34%), alopecia (26%), hyperkalemia (22%), nephrotoxicity (18%), post transplant diatetes mellitus (14%), hypertension (14%), and hypercholesterolemia (10%). However, the incidence of gum hypertrophy and hirsutism were 6% and 2%, respectively. Conclusion: This short-term study indicates that tacrolimus appears to provide safe and effective primary immunosuppression in kidney transplantation.
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