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신장 이식에서 일차 면역억제제로서 Tacrolimus의 효과

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Author(s)
김현철박성배한승엽황은아전동석김형태조원현박철희
Keimyung Author(s)
Kim, Hyun ChulPark, Sung BaeHan, Seung YeupJeon, Dong SeokHwang, Eun AhKim, Hyoung TaeCho, Won HyunPark, Choal Hee
Department
Dept. of Internal Medicine (내과학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Surgery (외과학)
Dept. of Urology (비뇨의학)
Kidney Institute (신장연구소)
Journal Title
대한이식학회지
Issued Date
2001
Volume
15
Issue
2
Abstract
Purpose: Tacrolimus (FK-506) represents a major advance in the prevention of rejection following solid organ transplantation. Previous clinical trials in Japan, Europe, and the US suggest that tacrolimus is an effective primary immunosuppressive agent in kidney transplantation. This prospective, non-randomized single center study was done to confirmed the efficacy of tacrolimus in kidney transplantation. Methods: A total of 50 renal transplant recipients who followed-up at least one year after transplantation was included in this study. Thirty six cases (72%) recived triple drug therapy consists of tacrolimus, mycophenolate mofetil (MMF), and low dose steroid. Results: The overall incidence of acute rejection was 10%, alt episodes of Section were treated effectively with steroid pulse therapy. The incidence of treatment failure was six percent. One and two year graft survival were 98% and 96%, respectively. Adverse effects of tacrolimus therapy included tremor of the hand (56%), diantiea (34%), alopecia (26%), hyperkalemia (22%), nephrotoxicity (18%), post transplant diatetes mellitus (14%), hypertension (14%), and hypercholesterolemia (10%). However, the incidence of gum hypertrophy and hirsutism were 6% and 2%, respectively. Conclusion: This short-term study indicates that tacrolimus appears to provide safe and effective primary immunosuppression in kidney transplantation.
Alternative Title
Primary Immunosuppression with Tacrolimus in Renal Transplantation -Single Center Experience -
Keimyung Author(s)(Kor)
김현철
박성배
한승엽
황은아
전동석
김형태
조원현
박철희
Publisher
School of Medicine
Citation
김현철 et al. (2001). 신장 이식에서 일차 면역억제제로서 Tacrolimus의 효과. 대한이식학회지, 15(2), 158–164.
Type
Article
ISSN
1598-1711
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38428
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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