지속성 및 재발성 자궁경부암에 대한 5-Fluorouracil 5일간 지속주입과 Cis-platinum의 복합화학요법

Abstract

28 patients with persistent or recurrent carcinoma of the cervix were treated with combined regimen, in which cisplatin at 100mg/m given intravenously on day 1 was combined with 5-fluorouracil, 1,000mg/m daily given as a 24-hr infusion on days 1∼5. Treatment cycle was repeated every 28 days. Among 27 patients with evaluable disease, the overall response was 63% (17 patients) including 6 patients with complete response. Overall medinan survival was 41.3 weeks; 50.3 weeks for response group and 22.6 weeks for nonresponse group. Toxicity of grade 3∼4 or over were, hematologic toxicity in 4 patients, and stomatitis in 2 patients, nausea and vomiting in 4 patients, infection in 1 patients, alopecia 8 patients, and diarrhea in 2 patients. There was one treatment related death, and the cause of death was severe mucositis and bone marrow depression followed by sepsis. These results show that cisplatinum and continuous infusion of 5-Fluorouracil combination regimen is effective for persistent or recurrent carcinoma of the cervix.