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지속성 및 재발성 자궁경부암에 대한 5-Fluorouracil 5일간 지속주입과 Cis-platinum의 복합화학요법

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Author(s)
이태성조치흠서영욱Tae Sung LeeChi Heum ChoYoung Wook Suh
Keimyung Author(s)
Lee, Tae SungCho, Chi HeumSuh, Young Wook
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
대한산부인과학회잡지
Issued Date
1992
Volume
35
Issue
5
Abstract
28 patients with persistent or recurrent carcinoma of the cervix were treated with combined regimen, in which cisplatin at 100mg/m given intravenously on day 1 was combined with 5-fluorouracil, 1,000mg/m daily given as a 24-hr infusion on days 1∼5. Treatment cycle was repeated every 28 days. Among 27 patients with evaluable disease, the overall response was 63% (17 patients) including 6 patients with complete response. Overall medinan survival was 41.3 weeks; 50.3 weeks for response group and 22.6 weeks for nonresponse group. Toxicity of grade 3∼4 or over were, hematologic toxicity in 4 patients, and stomatitis in 2 patients, nausea and vomiting in 4 patients, infection in 1 patients, alopecia 8 patients, and diarrhea in 2 patients. There was one treatment related death, and the cause of death was severe mucositis and bone marrow depression followed by sepsis. These results show that cisplatinum and continuous infusion of 5-Fluorouracil combination regimen is effective for persistent or recurrent carcinoma of the cervix.
Alternative Title
5-Fluorouracil Continuous Infusion and Cisplatinum Combination Chemotherapay for Persistent and Recurrent Carcinoma of the Cervix
Keimyung Author(s)(Kor)
이태성
조치흠
서영욱
Publisher
School of Medicine
Citation
이태성 et al. (1992). 지속성 및 재발성 자궁경부암에 대한 5-Fluorouracil 5일간 지속주입과 Cis-platinum의 복합화학요법. 대한산부인과학회잡지, 35(5), 751–757.
Type
Article
ISSN
0494-4755
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38939
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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