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흰쥐 피부의 반흔 형성과정에서 VEGF, TGF-β1 및 CTGF의 역할과 상호관계

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Author(s)
한기환박관규
Alternative Author(s)
Han, Ki HwanPark, Kwan Kyu
Issued Date
2004
Abstract
Skin fibrotic disorders are understood to develop under the influence of various cytokines, such as transforming growth factor(TGF)-beta1, connective tissue growth factor(CTGF) and vascular endothelial growth factor (VEGF). To establish an appropriate animal model of skin fibrosis by exogenous application of growth factors, the author investigated the in vivo effects of growth factors by injecting recombinant TGF-beta1 protein and pCMV- Flag5-CTGF into the subcutaneous tissue of Sprague- Dawley rats. A single application of TGF-beta1 protein and CTGF DNA resulted in the formation of transient granulation tissue. Immunohistochemical finding showed increased expression of TGF-beta1 protein after injection of pCMV-Flag5-CTGF. In situ hybridization analysis revealed the expression of CTGF mRNA after injection of TGF-beta1 protein. VEGF expression was not affected by the TGF-beta1 and CTGF injection. These findings suggest TGF-beta1 and CTGF are deeply related with skin fibrosis and it appears that TGF-beta1 may cause the induction of CTGF expression.
The animal model on skin fibrosis by exogenous application of TGF-beta1 protein and CTGF DNA developed in this study may be useful for future studies on fibrotic disorders.
Alternative Title
The Role and Relation of VEGF, TGF-β1 and CTGF in the Scar Formation of the Rat
Department
Dept. of Plastic Surgery (성형외과학)
Dept. of Pathology (병리학)
Kidney Institute (신장연구소)
Publisher
School of Medicine
Citation
대한성형외과학회지, Vol.31(1) : 110-118, 2004
Type
Article
ISSN
1015-6402
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/39222
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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