흰쥐에서 streptozotocin에 의해 유도된 당뇨병에 대한 운동과 melatonin의 효과

Abstract

The effects of melatonin and exercise on diabetes mellitus induced by streptozotocin in male Sprague-Dawley rats were studied. Diabetes was induced by the intraperitoneal injection of 65 mg of streptozotocin per kg of body weight. To know the effect of melatonin, a dose of 10 mg of melatonin per kg of body weight was administered intraperitoneally. And to know the effect of exercise, rats were performed exercise by a treadmill running at the speed of 10 m/minute, 8% of slope, for 60 minutes in a day for 1 week. The parameters including the levels of blood glucose, hemoglobin A1C, and malondialdehyde analysed to evaluate diabetic state and the degree of lipid peroxidation by oxygen free radicals. The injection of streptozotocin caused significant increases in the levels of blood glucose, hemoglobin A1C and malondialdehyde. Melatonin and exercise reduced significantly the levels of blood glucose, hemoglobin A1C and malondialdehyde which were increased by streptozotocin injection. When the effect of melatonin and exercise in the diabetic rats was compared the exercise was more effective for normalizing the parameters which were changed by streptozotocin injection than melatonin. These results may suggest that melatonin and exercise are effective the oxidative damage in the diabetes induced by streptozotocin. Exercise is more protective for diabetes mellitus than melatonin.